Pathway candidateNCBI-verifiedprotein-coding

ABCB11

ATP binding cassette subfamily B member 11

NCBI Gene: 8647 Ensembl GeneCards UniProt: O95342

Pathway candidate — not linked to PFS or PSSD by any record here

ABCB11 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in ABCB11 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 2 (drug and xenobiotic transporters). The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Bile salt export pump
Function: Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Subcellular location: Apical cell membrane; Recycling endosome membrane; Endosome; Cell membrane.
Tissue specificity: Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Associated conditions: Cholestasis, progressive familial intrahepatic, 2 (PFIC2); Cholestasis, benign recurrent intrahepatic, 2 (BRIC2).

Source: UniProtKB/Swiss-Prot O95342, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCB11 specifically.

Mentioned in 0 corpus records

No corpus record names ABCB11 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Bile salt export pump
Function: Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Subcellular location: Apical cell membrane; Recycling endosome membrane; Endosome; Cell membrane.
Tissue specificity: Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Associated conditions: Cholestasis, progressive familial intrahepatic, 2 (PFIC2); Cholestasis, benign recurrent intrahepatic, 2 (BRIC2).