ABCC2
ATP binding cassette subfamily C member 2
Theoretical — per Powers
Gene summary
A protein-coding gene on chromosome 10 (drug and xenobiotic transporters). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
ATP-binding cassette sub-family C member 2
- Function (excerpt)
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells where it mediates hepatobiliary and renal excretion of conjugated substrates. Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification. Mediates the efflux of steroid glucuronates from intestine and liver into the intestinal lumen. Shares substrate specificity with MRP3 but displays lower affinity and higher transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates. Transports glutathione conjugate leukotriene C4 (LTC4) and related cysteinyl leukotrienes.
- Subcellular location
Apical cell membrane.
- Tissue specificity
Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine.
- Associated conditions
Dubin-Johnson syndrome (DJS).
Source: UniProtKB/Swiss-Prot Q92887, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.
Written for the whole drug transporters family, not for ABCC2 specifically.
Powers’ note (his unpublished theorizing)
Powers named the ABCC transporter family (2026 summit interview, unpublished) as intracellular transporter genes implicated in metabolite clearance in his experimentally verifiable mechanism; individual ABCC members not separately named.
Narrative library record
Function
Apical membrane efflux pump (MRP2) of liver, kidney, and intestine that exports organic anions - including bilirubin glucuronides and drug conjugates - out of cells for elimination. Loss causes Dubin-Johnson syndrome; polymorphisms alter drug pharmacokinetics.
Corpus relevance
Named among the transporter genes in Powers' DWP-002 model: after UGTs conjugate androgen metabolites, ABCC-family pumps must export them; a defect anywhere in the conjugate-then-export chain backs metabolites up intracellularly. Attribution: theoretical-per-Powers.
Mentioned in 5 corpus records
- Powers · Reddit commentCurated Powers pick
Re: I collect more and more labs/genome/dutch tests that support my theory on PFS. I really think I have it nailed down. I d...
u/drwillpowers · r/DrWillPowers
Powers argued that finasteride is an irreversible "suicide inhibitor" that permanently disables any 5AR enzyme it touches, requiring 2–3 weeks for the enzyme to be degraded and remade — so even a single pill can suffice if the patient's system is already at…
ABCC2ABCC5COMTPRH-13632026-04-04T15:55:18ZPFSPSSDPowers Reddit history - Gene recordPowers’ theory
UGT1A1 — UDP glucuronosyltransferase family 1 member A1
chromosome 2 (2q37 region; 233.76-233.77 Mb GRCh38)
UDP-glucuronosyltransferase that conjugates glucuronic acid onto lipophilic molecules - steroids, bilirubin, hormones, drugs - converting them to water-soluble, excretable metabolites. Over 100 described variants alter its activity (for example, Gilbert…
ABCC2ABCC3UGT1A1UGT2B15UGT2B17+1GENE-UGT1A1PFSCore corpus - Gene recordPowers’ theory
UGT2B7 — UDP glucuronosyltransferase family 2 member B7
chromosome 4 (UGT2B gene cluster, 4q13 region)
Broad-specificity glucuronosyltransferase of the UGT2B cluster that conjugates steroid hormones and many drugs for excretion; handles a wide substrate range including opioids and NSAIDs alongside endogenous steroids.
ABCC2UGT1A1UGT2B15UGT2B17UGT2B7GENE-UGT2B7Core corpus - Gene recordPowers’ theory
Basolateral membrane efflux pump (MRP3) of liver, intestine, kidney, adrenals, and pancreas that exports organic anions - bile constituents, bilirubin glucuronides, steroid conjugates - into blood for renal elimination; upregulated when ABCC2 fails, showing…
ABCC2ABCC3UGT2B15UGT2B17GENE-ABCC3Core corpus - Gene recordPowers’ theory
Encodes OATP1B1, the sodium-independent organic-anion transporter on liver cell membranes that moves bilirubin, hormones, toxins, and many drugs from blood into the liver for clearance; biallelic loss together with SLCO1B3 causes Rotor syndrome (conjugated…
ABCC2ABCC3SLCO1B1SLCO1B3UGT1A1+2GENE-SLCO1B1PFSCore corpus
Also in drug and xenobiotic transporters
All 62 genes- SLC6A4
solute carrier family 6 member 4
chr 17· Drug transporters· 10 records - ABCC3Powers
ATP binding cassette subfamily C member 3
chr 17· Drug transporters· 5 records - ABCB1
ATP binding cassette subfamily B member 1
chr 7· Drug transporters· 3 records - ABCC5Powers
ATP binding cassette subfamily C member 5
chr 3· Drug transporters· 3 records - SLCO1B1Powers
solute carrier organic anion transporter family member 1B1
chr 12· Drug transporters· 4 records - SLC18A2
solute carrier family 18 member A2
chr 10· Drug transporters· 1 record - SLCO1B3
solute carrier organic anion transporter family member 1B3
chr 12· Drug transporters· 1 record - ABCB11
ATP binding cassette subfamily B member 11
chr 2· Drug transporters· Pathway candidate
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