Pathway candidateNCBI-verifiedprotein-coding

ABCB6

ATP binding cassette subfamily B member 6 (LAN blood group)

NCBI Gene: 10058 Ensembl GeneCards UniProt: Q9NP58

Pathway candidate — not linked to PFS or PSSD by any record here

ABCB6 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in ABCB6 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 2 (drug and xenobiotic transporters). Encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family B member 6
Function: ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis (By similarity).
Subcellular location: Cell membrane; Mitochondrion outer membrane; Endoplasmic reticulum membrane; Golgi apparatus membrane; Endosome membrane; Lysosome membrane; Late endosome membrane; Early endosome membrane; Secreted, extracellular exosome; Mitochondrion; Endosome, multivesicular body membrane; Melanosome membrane.
Tissue specificity: Widely expressed. High expression is detected in the retinal epithelium. Expressed in mature erythrocytes.
Associated conditions: Microphthalmia/Coloboma 7 (MCOPCB7); Dyschromatosis universalis hereditaria 3 (DUH3); Pseudohyperkalemia, familial, 2, due to red cell leak (PSHK2).

Source: UniProtKB/Swiss-Prot Q9NP58, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCB6 specifically.

Mentioned in 0 corpus records

No corpus record names ABCB6 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family B member 6
Function: ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis (By similarity).
Subcellular location: Cell membrane; Mitochondrion outer membrane; Endoplasmic reticulum membrane; Golgi apparatus membrane; Endosome membrane; Lysosome membrane; Late endosome membrane; Early endosome membrane; Secreted, extracellular exosome; Mitochondrion; Endosome, multivesicular body membrane; Melanosome membrane.
Tissue specificity: Widely expressed. High expression is detected in the retinal epithelium. Expressed in mature erythrocytes.
Associated conditions: Microphthalmia/Coloboma 7 (MCOPCB7); Dyschromatosis universalis hereditaria 3 (DUH3); Pseudohyperkalemia, familial, 2, due to red cell leak (PSHK2).