Pathway candidateNCBI-verifiedprotein-coding

ABCB7

ATP binding cassette subfamily B member 7

NCBI Gene: 22 Ensembl GeneCards UniProt: O75027

Pathway candidate — not linked to PFS or PSSD by any record here

ABCB7 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in ABCB7 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (drug and xenobiotic transporters). The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Iron-sulfur clusters transporter ABCB7, mitochondrial
Function: Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity).
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Spinocerebellar ataxia, X-linked 6, with or without sideroblastic anemia (SCAX6).

Source: UniProtKB/Swiss-Prot O75027, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCB7 specifically.

Mentioned in 0 corpus records

No corpus record names ABCB7 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Iron-sulfur clusters transporter ABCB7, mitochondrial
Function: Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity).
Subcellular location: Mitochondrion inner membrane.
Associated conditions: Spinocerebellar ataxia, X-linked 6, with or without sideroblastic anemia (SCAX6).