Pathway candidateNCBI-verifiedprotein-coding

ABCB8

ATP binding cassette subfamily B member 8

NCBI Gene: 11194 Ensembl GeneCards UniProt: Q9NUT2

Pathway candidate — not linked to PFS or PSSD by any record here

ABCB8 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in ABCB8 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 7 (drug and xenobiotic transporters). This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mitochondrial potassium channel ATP-binding subunit
Function: ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
Subcellular location: Mitochondrion inner membrane.
Tissue specificity: Ubiquitous.

Source: UniProtKB/Swiss-Prot Q9NUT2, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCB8 specifically.

Mentioned in 0 corpus records

No corpus record names ABCB8 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mitochondrial potassium channel ATP-binding subunit
Function: ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
Subcellular location: Mitochondrion inner membrane.
Tissue specificity: Ubiquitous.