Powers’ theory onlyNamed by PowersNCBI-verifiedprotein-coding

ABCC1

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

NCBI Gene: 4363 Ensembl GeneCards UniProt: P33527

Named by Dr Will Powers — at family level only

Dr Powers’ claim covers ABCC1 only as part of a broader group (see his note below), and no record in the corpus names ABCC1 individually. This is unpublished theorizing, not an established finding. Research use only, not medical advice.

Gene summary

A protein-coding gene on chromosome 16 (drug and xenobiotic transporters). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family C member 1
Function (excerpt): ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels. Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity).
Subcellular location: Cell membrane; Basolateral cell membrane.
Tissue specificity: Lung, testis and peripheral blood mononuclear cells.
Associated conditions: Deafness, autosomal dominant, 77 (DFNA77).

Source: UniProtKB/Swiss-Prot P33527, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCC1 specifically.

Powers’ note (his unpublished theorizing)

Powers named the ABCC transporter family (2026 summit interview, unpublished) as intracellular transporter genes implicated in metabolite clearance in his experimentally verifiable mechanism; individual ABCC members not separately named.

Mentioned in 0 corpus records

No corpus record names ABCC1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family C member 1
Function (excerpt): ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels. Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity).
Subcellular location: Cell membrane; Basolateral cell membrane.
Tissue specificity: Lung, testis and peripheral blood mononuclear cells.
Associated conditions: Deafness, autosomal dominant, 77 (DFNA77).