Powers’ theory onlyNamed by PowersNCBI-verifiedprotein-coding

ABCC9

ATP binding cassette subfamily C member 9

NCBI Gene: 10060 Ensembl GeneCards UniProt: O60706

Named by Dr Will Powers — at family level only

Dr Powers’ claim covers ABCC9 only as part of a broader group (see his note below), and no record in the corpus names ABCC9 individually. This is unpublished theorizing, not an established finding. Research use only, not medical advice.

Gene summary

A protein-coding gene on chromosome 12 (drug and xenobiotic transporters). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family C member 9
Function: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (By similarity).
Subcellular location: Membrane.
Associated conditions: Cardiomyopathy, dilated, 1O (CMD1O); Atrial fibrillation, familial, 12 (ATFB12); Hypertrichotic osteochondrodysplasia (HTOCD); Intellectual disability and myopathy syndrome (IDMYS).

Source: UniProtKB/Swiss-Prot O60706, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCC9 specifically.

Powers’ note (his unpublished theorizing)

Powers named the ABCC transporter family (2026 summit interview, unpublished) as intracellular transporter genes implicated in metabolite clearance in his experimentally verifiable mechanism; individual ABCC members not separately named.

Mentioned in 0 corpus records

No corpus record names ABCC9 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family C member 9
Function: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (By similarity).
Subcellular location: Membrane.
Associated conditions: Cardiomyopathy, dilated, 1O (CMD1O); Atrial fibrillation, familial, 12 (ATFB12); Hypertrichotic osteochondrodysplasia (HTOCD); Intellectual disability and myopathy syndrome (IDMYS).