Pathway candidateNCBI-verifiedprotein-coding

ABCG1

ATP binding cassette subfamily G member 1

NCBI Gene: 9619 Ensembl GeneCards UniProt: P45844

Pathway candidate — not linked to PFS or PSSD by any record here

ABCG1 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in ABCG1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 21 (drug and xenobiotic transporters). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family G member 1
Function: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.
Subcellular location: Endoplasmic reticulum membrane; Golgi apparatus membrane; Cell membrane.
Tissue specificity: Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

Source: UniProtKB/Swiss-Prot P45844, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCG1 specifically.

Mentioned in 0 corpus records

No corpus record names ABCG1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family G member 1
Function: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.
Subcellular location: Endoplasmic reticulum membrane; Golgi apparatus membrane; Cell membrane.
Tissue specificity: Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.