Pathway candidateNCBI-verifiedprotein-coding

ABCG4

ATP binding cassette subfamily G member 4

NCBI Gene: 64137 Ensembl GeneCards UniProt: Q9H172

Pathway candidate — not linked to PFS or PSSD by any record here

ABCG4 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in ABCG4 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (drug and xenobiotic transporters). The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family G member 4
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells.
Subcellular location: Cell membrane; Cytoplasmic vesicle membrane; Endosome membrane.
Tissue specificity: Expressed specifically in the brain and the eye.

Source: UniProtKB/Swiss-Prot Q9H172, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for ABCG4 specifically.

Mentioned in 0 corpus records

No corpus record names ABCG4 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: ATP-binding cassette sub-family G member 4
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells.
Subcellular location: Cell membrane; Cytoplasmic vesicle membrane; Endosome membrane.
Tissue specificity: Expressed specifically in the brain and the eye.