AHCY
adenosylhomocysteinase
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 20 (methylation and one-carbon metabolism). S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy).
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Adenosylhomocysteinase
- Function
Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine. Binds copper ions (By similarity).
- Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
- Subcellular location
Cytoplasm; Melanosome; Nucleus; Endoplasmic reticulum.
- Associated conditions
Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD).
Source: UniProtKB/Swiss-Prot P23526, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
One-carbon metabolism supplies methyl groups for DNA/histone methylation — the epigenetic layer implicated in persistent post-drug changes.
Written for the whole methylation / one-carbon family, not for AHCY specifically.
Mentioned in 0 corpus records
No corpus record names AHCY directly yet. It is in the library because it sits in a pathway the corpus tracks (Methylation / one-carbon).
Also in methylation and one-carbon metabolism
All 5 genes- MTHFRPowers
methylenetetrahydrofolate reductase
chr 1· Methylation / one-carbon· 4 records - BHMT
betaine--homocysteine S-methyltransferase
chr 5· Methylation / one-carbon· Pathway candidate - MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
chr 1· Methylation / one-carbon· Pathway candidate - MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr 5· Methylation / one-carbon· Pathway candidate
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