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Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
These proteins take vitamin A from blood to gene regulation: RBP4 carries retinol, STRA6 takes it into cells, LRAT stores it, RDH10 and the ALDH1A enzymes turn it into retinoic acid (DHRS3 reverses the first step), CRABP2 carries retinoic acid to the nucleus, the RAR and RXR receptors act on it, and CYP26A1 and CYP26B1 break it down. Isotretinoin, the drug behind post-retinoid sexual dysfunction, is a retinoid; and several retinol dehydrogenases (RDH16, HSD17B6, RDH5) also oxidize androgen metabolites such as 3α-androstanediol, a point of contact with the steroid pathways implicated in PFS.
Sorted by how often each gene is cited in corpus records, then alphabetically.
aldo-keto reductase family 1 member C3
aldehyde dehydrogenase 1 family member A1
aldehyde dehydrogenase 1 family member A2
aldehyde dehydrogenase 1 family member A3
cellular retinoic acid binding protein 2
cytochrome P450 family 2 subfamily C member 8
cytochrome P450 family 26 subfamily A member 1
cytochrome P450 family 26 subfamily B member 1
dehydrogenase/reductase 3
hydroxysteroid 17-beta dehydrogenase 6
lecithin retinol acyltransferase
retinoic acid receptor alpha
retinoic acid receptor beta
retinoic acid receptor gamma
retinol binding protein 1
retinol binding protein 4
retinol dehydrogenase 5
retinol dehydrogenase 10
retinol dehydrogenase 16
retinoid X receptor alpha
retinoid X receptor beta
retinoid X receptor gamma
signaling receptor and transporter of retinol STRA6