Pathway candidateNCBI-verifiedprotein-coding

ALDH1A2

aldehyde dehydrogenase 1 family member A2

Chromosome 15Drug metabolism retinoid signaling

NCBI Gene: 8854 Ensembl GeneCards UniProt: O94788

Pathway candidate — not linked to PFS or PSSD by any record here

ALDH1A2 is in the library because it belongs to the drug metabolism / retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in ALDH1A2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 15 (drug metabolism (phase i)). This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinal dehydrogenase 2
Function: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity).
Pathway: Cofactor metabolism; retinol metabolism.
Subcellular location: Cytoplasm.
Associated conditions: Diaphragmatic hernia 4, with cardiovascular defects (DIH4).

Source: UniProtKB/Swiss-Prot O94788, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Phase I enzymes determine exposure to finasteride, SSRIs, and other implicated drugs; variation here shapes the likelihood and persistence of adverse effects.

Written for the whole drug metabolism / retinoid signaling family, not for ALDH1A2 specifically.

Mentioned in 0 corpus records

No corpus record names ALDH1A2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug metabolism, retinoid signaling).

Also in drug metabolism (phase i)

All 23 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Retinal dehydrogenase 2
Function: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity).
Pathway: Cofactor metabolism; retinol metabolism.
Subcellular location: Cytoplasm.
Associated conditions: Diaphragmatic hernia 4, with cardiovascular defects (DIH4).