Pathway candidateNCBI-verifiedprotein-coding

ARID1B

AT-rich interaction domain 1B

NCBI Gene: 57492 Ensembl GeneCards UniProt: Q8NFD5

Pathway candidate — not linked to PFS or PSSD by any record here

ARID1B is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in ARID1B is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 6 (epigenetic regulation). This locus encodes an AT-rich DNA interacting domain-containing protein. The protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: AT-rich interactive domain-containing protein 1B
Function (excerpt): Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.
Subcellular location: Nucleus.
Tissue specificity: Widely expressed with high levels in heart, skeletal muscle and kidney.
Associated conditions: Coffin-Siris syndrome 1 (CSS1).

Source: UniProtKB/Swiss-Prot Q8NFD5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for ARID1B specifically.

Mentioned in 0 corpus records

No corpus record names ARID1B directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

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Protein reference (UniProt)

Protein: AT-rich interactive domain-containing protein 1B
Function (excerpt): Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.
Subcellular location: Nucleus.
Tissue specificity: Widely expressed with high levels in heart, skeletal muscle and kidney.
Associated conditions: Coffin-Siris syndrome 1 (CSS1).