Pathway candidateNCBI-verifiedprotein-coding

ARSG

arylsulfatase G

NCBI Gene: 22901 Ensembl GeneCards UniProt: Q96EG1

Pathway candidate — not linked to PFS or PSSD by any record here

ARSG is in the library because it belongs to the conjugation & clearance family. No study, report or commentary in the corpus names it, so a variant in ARSG is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (steroid conjugation and clearance). The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Arylsulfatase G
Function: Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
Subcellular location: Lysosome.
Tissue specificity: Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
Associated conditions: Usher syndrome 4 (USH4).

Source: UniProtKB/Swiss-Prot Q96EG1, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.

Written for the whole conjugation & clearance family, not for ARSG specifically.

Mentioned in 0 corpus records

No corpus record names ARSG directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).

Also in steroid conjugation and clearance

All 31 genes

Browse by family on the gene families page.

Pathway candidateNCBI-verifiedprotein-coding

ARSG

arylsulfatase G

Chromosome 17Conjugation & clearance

NCBI Gene: 22901 Ensembl GeneCards UniProt: Q96EG1

Pathway candidate — not linked to PFS or PSSD by any record here

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Arylsulfatase G
Function: Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
Subcellular location: Lysosome.
Tissue specificity: Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
Associated conditions: Usher syndrome 4 (USH4).

Why its pathway is in the library

Written for the whole conjugation & clearance family, not for ARSG specifically.

Mentioned in 0 corpus records

No corpus record names ARSG directly yet. It is in the library because it sits in a pathway the corpus tracks (Conjugation & clearance).

Also in steroid conjugation and clearance

All 31 genes

Browse by family on the gene families page.