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Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
Phase II enzymes — UGT glucuronidation, SULT sulfation, and the sulfatases that reverse it — are the exit routes for androgens and their metabolites. Powers' current PFS model centers on broken clearance: defective UGT2B17/SULT2A1 trapping androgens intracellularly, with SLCO1B1 implicated in recycling of the conjugates. Gut bacterial beta-glucuronidase can undo glucuronidation, linking this family to the microbiome findings.
Sorted by how often each gene is cited in corpus records, then alphabetically.
UDP glucuronosyltransferase family 2 member B17
UDP glucuronosyltransferase family 2 member B15
aldo-keto reductase family 1 member C2
UDP glucuronosyltransferase family 2 member B7
aldo-keto reductase family 1 member C3
aldo-keto reductase family 1 member C4
aldo-keto reductase family 1 member C1
sulfotransferase family 2A member 1
UDP glucuronosyltransferase family 1 member A1
arylsulfatase A
arylsulfatase G
glucuronidase beta
3'-phosphoadenosine 5'-phosphosulfate synthase 1
3'-phosphoadenosine 5'-phosphosulfate synthase 2
steroid sulfatase
sulfotransferase family 1A member 1
sulfotransferase family 1A member 2
sulfotransferase family 1E member 1
sulfotransferase family 2B member 1
sulfatase modifying factor 1
sulfatase modifying factor 2
UDP-glucose 6-dehydrogenase
UDP-glucose pyrophosphorylase 2
UDP glucuronosyltransferase family 1 member A3
UDP glucuronosyltransferase family 1 member A4
UDP glucuronosyltransferase family 1 member A6
UDP glucuronosyltransferase family 1 member A8
UDP glucuronosyltransferase family 1 member A9
UDP glucuronosyltransferase family 1 member A10
UDP glucuronosyltransferase family 2 member B10
UDP glucuronosyltransferase family 2 member B28