Pathway candidateNCBI-verifiedprotein-coding

BAG3

BAG cochaperone 3

NCBI Gene: 9531 Ensembl GeneCards UniProt: O95817

Pathway candidate — not linked to PFS or PSSD by any record here

BAG3 is in the library because it belongs to the receptor chaperones family. No study, report or commentary in the corpus names it, so a variant in BAG3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (steroid receptor chaperones). BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: BAG family molecular chaperone regulator 3
Function: Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
Subcellular location: Nucleus; Cytoplasm.
Associated conditions: Myopathy, myofibrillar, 6 (MFM6); Cardiomyopathy, dilated, 1HH (CMD1HH); Neuronopathy, distal hereditary motor, autosomal dominant 15 (HMND15); Charcot-Marie-Tooth disease, axonal, type 2JJ (CMT2JJ).

Source: UniProtKB/Swiss-Prot O95817, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Chaperone/co-chaperone control of steroid-receptor folding and sensitivity is a regulatory layer above the receptors themselves, tied to stress-axis signaling.

Written for the whole receptor chaperones family, not for BAG3 specifically.

Mentioned in 0 corpus records

No corpus record names BAG3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Receptor chaperones).

Also in steroid receptor chaperones

All 14 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: BAG family molecular chaperone regulator 3
Function: Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
Subcellular location: Nucleus; Cytoplasm.
Associated conditions: Myopathy, myofibrillar, 6 (MFM6); Cardiomyopathy, dilated, 1HH (CMD1HH); Neuronopathy, distal hereditary motor, autosomal dominant 15 (HMND15); Charcot-Marie-Tooth disease, axonal, type 2JJ (CMT2JJ).