Pathway candidateNCBI-verifiedprotein-coding

FKBP5

FKBP prolyl isomerase 5

NCBI Gene: 2289 Ensembl GeneCards UniProt: Q13451

Pathway candidate — not linked to PFS or PSSD by any record here

FKBP5 is in the library because it belongs to the receptor chaperones family. No study, report or commentary in the corpus names it, so a variant in FKBP5 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 6 (steroid receptor chaperones). The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Peptidyl-prolyl cis-trans isomerase FKBP5
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production.
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Widely expressed, enriched in testis compared to other tissues.

Source: UniProtKB/Swiss-Prot Q13451, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Chaperone/co-chaperone control of steroid-receptor folding and sensitivity is a regulatory layer above the receptors themselves, tied to stress-axis signaling.

Written for the whole receptor chaperones family, not for FKBP5 specifically.

Mentioned in 0 corpus records

No corpus record names FKBP5 directly yet. It is in the library because it sits in a pathway the corpus tracks (Receptor chaperones).

Also in steroid receptor chaperones

All 14 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Peptidyl-prolyl cis-trans isomerase FKBP5
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production.
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Widely expressed, enriched in testis compared to other tissues.