Pathway candidateNCBI-verifiedprotein-coding

FKBP6

FKBP prolyl isomerase family member 6 (inactive)

NCBI Gene: 8468 Ensembl GeneCards UniProt: O75344

Pathway candidate — not linked to PFS or PSSD by any record here

FKBP6 is in the library because it belongs to the receptor chaperones family. No study, report or commentary in the corpus names it, so a variant in FKBP6 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 7 (steroid receptor chaperones). The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Function: Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
Associated conditions: Spermatogenic failure 77 (SPGF77).

Source: UniProtKB/Swiss-Prot O75344, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Chaperone/co-chaperone control of steroid-receptor folding and sensitivity is a regulatory layer above the receptors themselves, tied to stress-axis signaling.

Written for the whole receptor chaperones family, not for FKBP6 specifically.

Mentioned in 0 corpus records

No corpus record names FKBP6 directly yet. It is in the library because it sits in a pathway the corpus tracks (Receptor chaperones).

Also in steroid receptor chaperones

All 14 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Inactive peptidyl-prolyl cis-trans isomerase FKBP6
Function: Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
Associated conditions: Spermatogenic failure 77 (SPGF77).