Pathway candidateNCBI-verifiedprotein-coding

BPTF

bromodomain PHD finger transcription factor

NCBI Gene: 2186 Ensembl GeneCards UniProt: Q12830

Pathway candidate — not linked to PFS or PSSD by any record here

BPTF is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in BPTF is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (epigenetic regulation). This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nucleosome-remodeling factor subunit BPTF
Function: Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
Associated conditions: Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL).

Source: UniProtKB/Swiss-Prot Q12830, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for BPTF specifically.

Mentioned in 0 corpus records

No corpus record names BPTF directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Nucleosome-remodeling factor subunit BPTF
Function: Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
Subcellular location: Cytoplasm; Nucleus.
Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
Associated conditions: Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL).