Pathway candidateNCBI-verifiedprotein-coding

BRPF1

bromodomain and PHD finger containing 1

NCBI Gene: 7862 Ensembl GeneCards UniProt: P55201

Pathway candidate — not linked to PFS or PSSD by any record here

BRPF1 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in BRPF1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (epigenetic regulation). Encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Peregrin
Function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation. Positively regulates the transcription of RUNX1 and RUNX2.
Subcellular location: Nucleus; Chromosome; Cytoplasm.
Tissue specificity: High levels in testis.
Associated conditions: Intellectual developmental disorder with dysmorphic facies and ptosis (IDDDFP).

Source: UniProtKB/Swiss-Prot P55201, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for BRPF1 specifically.

Mentioned in 0 corpus records

No corpus record names BRPF1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Peregrin
Function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation. Positively regulates the transcription of RUNX1 and RUNX2.
Subcellular location: Nucleus; Chromosome; Cytoplasm.
Tissue specificity: High levels in testis.
Associated conditions: Intellectual developmental disorder with dysmorphic facies and ptosis (IDDDFP).