Pathway candidateNCBI-verifiedprotein-coding

CHD2

chromodomain helicase DNA binding protein 2

NCBI Gene: 1106 Ensembl GeneCards UniProt: O14647

Pathway candidate — not linked to PFS or PSSD by any record here

CHD2 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in CHD2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 15 (epigenetic regulation). Belongs to the CHD family, proteins characterized by chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure, altering access of the transcriptional apparatus to its chromosomal DNA template.

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried DSCAM's record.

Protein reference (UniProt)

Protein: ATP-dependent chromatin remodeler CHD2
Function: ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
Subcellular location: Nucleus.
Associated conditions: Developmental and epileptic encephalopathy 94 (DEE94).

Source: UniProtKB/Swiss-Prot O14647, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for CHD2 specifically.

Mentioned in 0 corpus records

No corpus record names CHD2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

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Gene summary

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried DSCAM's record.

Protein reference (UniProt)

Protein: ATP-dependent chromatin remodeler CHD2
Function: ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
Subcellular location: Nucleus.
Associated conditions: Developmental and epileptic encephalopathy 94 (DEE94).