CHD3
chromodomain helicase DNA binding protein 3
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 17 (epigenetic regulation). Encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
ATP-dependent chromatin remodeler CHD3
- Function
ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Involved in transcriptional repression as part of the NuRD complex. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
- Subcellular location
Nucleus, PML body; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
- Tissue specificity
Widely expressed.
- Associated conditions
Snijders Blok-Campeau syndrome (SNIBCPS).
Source: UniProtKB/Swiss-Prot Q12873, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.
Written for the whole epigenetic regulation family, not for CHD3 specifically.
Mentioned in 0 corpus records
No corpus record names CHD3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).
Also in epigenetic regulation
All 130 genes- HDAC10Powers
histone deacetylase 10
chr 22· Epigenetic regulation· 11 records - ARID1APowers
AT-rich interaction domain 1A
chr 1· Epigenetic regulation· 10 records - CHD8Powers
chromodomain helicase DNA binding protein 8
chr 14· Epigenetic regulation· 9 records - CHD4
chromodomain helicase DNA binding protein 4
chr 12· Epigenetic regulation· 1 record - CHD5
chromodomain helicase DNA binding protein 5
chr 1· Epigenetic regulation· 1 record - CHD6
chromodomain helicase DNA binding protein 6
chr 20· Epigenetic regulation· 1 record - CHD7
chromodomain helicase DNA binding protein 7
chr 8· Epigenetic regulation· 1 record - CHD9
chromodomain helicase DNA binding protein 9
chr 16· Epigenetic regulation· 1 record
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