Pathway candidateNCBI-verifiedprotein-coding

DPF2

double PHD fingers 2

NCBI Gene: 5977 Ensembl GeneCards UniProt: Q92785

Pathway candidate — not linked to PFS or PSSD by any record here

DPF2 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in DPF2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (epigenetic regulation). The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Zinc finger protein ubi-d4
Function: Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway.
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Ubiquitous.
Associated conditions: Coffin-Siris syndrome 7 (CSS7).

Source: UniProtKB/Swiss-Prot Q92785, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for DPF2 specifically.

Mentioned in 0 corpus records

No corpus record names DPF2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.

Pathway candidateNCBI-verifiedprotein-coding

DPF2

double PHD fingers 2

Chromosome 11Epigenetic regulation

NCBI Gene: 5977 Ensembl GeneCards UniProt: Q92785

Pathway candidate — not linked to PFS or PSSD by any record here

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Zinc finger protein ubi-d4
Function: Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway.
Subcellular location: Nucleus; Cytoplasm.
Tissue specificity: Ubiquitous.
Associated conditions: Coffin-Siris syndrome 7 (CSS7).

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for DPF2 specifically.

Mentioned in 0 corpus records

No corpus record names DPF2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.