Pathway candidateNCBI-verifiedprotein-coding

EP400

E1A binding protein p400

NCBI Gene: 57634 Ensembl GeneCards UniProt: Q96L91

Pathway candidate — not linked to PFS or PSSD by any record here

EP400 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in EP400 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (epigenetic regulation). Predicted to enable chromatin binding activity. Involved in nervous system development; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: E1A-binding protein p400
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitously expressed.

Source: UniProtKB/Swiss-Prot Q96L91, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for EP400 specifically.

Mentioned in 0 corpus records

No corpus record names EP400 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: E1A-binding protein p400
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitously expressed.