Pathway candidateNCBI-verifiedprotein-coding

INO80

INO80 complex ATPase subunit

NCBI Gene: 54617 Ensembl GeneCards UniProt: Q9ULG1

Pathway candidate — not linked to PFS or PSSD by any record here

INO80 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in INO80 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 15 (epigenetic regulation). Encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Chromatin-remodeling ATPase INO80
Function: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.
Subcellular location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle; Chromosome.
Tissue specificity: According to PMID 10574462, widely expressed. According to PMID 16298340, specifically expressed in brain, liver and pancreas.

Source: UniProtKB/Swiss-Prot Q9ULG1, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for INO80 specifically.

Mentioned in 0 corpus records

No corpus record names INO80 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Chromatin-remodeling ATPase INO80
Function: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.
Subcellular location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle; Chromosome.
Tissue specificity: According to PMID 10574462, widely expressed. According to PMID 16298340, specifically expressed in brain, liver and pancreas.