Pathway candidateNCBI-verifiedprotein-coding

KAT2A

lysine acetyltransferase 2A

NCBI Gene: 2648 Ensembl GeneCards UniProt: Q92830

Pathway candidate — not linked to PFS or PSSD by any record here

KAT2A is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in KAT2A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (epigenetic regulation). KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 ).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone acetyltransferase KAT2A
Function (excerpt): Protein lysine acyltransferase that catalyzes acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyzes acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.
Subcellular location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue specificity: Expressed in all tissues tested.

Source: UniProtKB/Swiss-Prot Q92830, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for KAT2A specifically.

Mentioned in 0 corpus records

No corpus record names KAT2A directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone acetyltransferase KAT2A
Function (excerpt): Protein lysine acyltransferase that catalyzes acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyzes acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.
Subcellular location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue specificity: Expressed in all tissues tested.