Pathway candidateNCBI-verifiedprotein-coding

KAT6A

lysine acetyltransferase 6A

NCBI Gene: 7994 Ensembl GeneCards UniProt: Q92794

Pathway candidate — not linked to PFS or PSSD by any record here

KAT6A is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in KAT6A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 8 (epigenetic regulation). Encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone acetyltransferase KAT6A
Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. May play a role in leukemogenic gene transcription.
Subcellular location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body.
Associated conditions: Arboleda-Tham syndrome (ARTHS).

Source: UniProtKB/Swiss-Prot Q92794, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for KAT6A specifically.

Mentioned in 0 corpus records

No corpus record names KAT6A directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone acetyltransferase KAT6A
Function: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. May play a role in leukemogenic gene transcription.
Subcellular location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body.
Associated conditions: Arboleda-Tham syndrome (ARTHS).