KDM1A

Source: NCBI Gene, accessed 2026-10-07.

Protein

Lysine-specific histone demethylase 1A

Function (excerpt)

Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression.

Subcellular location

Nucleus; Chromosome.

Tissue specificity

Ubiquitously expressed.

Associated conditions

Cleft palate, psychomotor retardation, and distinctive facial features (CPRF); ACTH-independent macronodular adrenal hyperplasia 3 (AIMAH3).

Source: UniProtKB/Swiss-Prot O60341, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Written for the whole epigenetic regulation family, not for KDM1A specifically.