Pathway candidateNCBI-verifiedprotein-coding

KDM2B

lysine demethylase 2B

NCBI Gene: 84678 Ensembl GeneCards UniProt: Q8NHM5

Pathway candidate — not linked to PFS or PSSD by any record here

KDM2B is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in KDM2B is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (epigenetic regulation). Encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Lysine-specific demethylase 2B
Function: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
Subcellular location: Nucleus, nucleolus; Nucleus; Chromosome.
Associated conditions: Neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities (NEDCRO).

Source: UniProtKB/Swiss-Prot Q8NHM5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for KDM2B specifically.

Mentioned in 0 corpus records

No corpus record names KDM2B directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Lysine-specific demethylase 2B
Function: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
Subcellular location: Nucleus, nucleolus; Nucleus; Chromosome.
Associated conditions: Neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities (NEDCRO).