Pathway candidateNCBI-verifiedprotein-coding

KDM5A

lysine demethylase 5A

NCBI Gene: 5927 Ensembl GeneCards UniProt: P29375

Pathway candidate — not linked to PFS or PSSD by any record here

KDM5A is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in KDM5A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (epigenetic regulation). Encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Lysine-specific demethylase 5A
Function (excerpt): Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
Subcellular location: Nucleus, nucleolus; Nucleus.
Associated conditions: El Hayek-Chahrour neurodevelopmental syndrome (NEDEHC).

Source: UniProtKB/Swiss-Prot P29375, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for KDM5A specifically.

Mentioned in 0 corpus records

No corpus record names KDM5A directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Lysine-specific demethylase 5A
Function (excerpt): Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
Subcellular location: Nucleus, nucleolus; Nucleus.
Associated conditions: El Hayek-Chahrour neurodevelopmental syndrome (NEDEHC).