Pathway candidateNCBI-verifiedprotein-coding

KDM5D

lysine demethylase 5D

NCBI Gene: 8284 Ensembl GeneCards UniProt: Q9BY66

Pathway candidate — not linked to PFS or PSSD by any record here

KDM5D is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in KDM5D is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome Y (epigenetic regulation). Encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Lysine-specific demethylase 5D
Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Subcellular location: Nucleus.
Tissue specificity: Expression is highly down-regulated in metastatic prostate tumors.

Source: UniProtKB/Swiss-Prot Q9BY66, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for KDM5D specifically.

Mentioned in 0 corpus records

No corpus record names KDM5D directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Lysine-specific demethylase 5D
Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Subcellular location: Nucleus.
Tissue specificity: Expression is highly down-regulated in metastatic prostate tumors.