KDM6A
lysine demethylase 6A
Gene summary
A protein-coding gene on chromosome X (epigenetic regulation). This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Lysine-specific demethylase 6A
- Function
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).
- Subcellular location
Nucleus.
- Associated conditions
Kabuki syndrome 2 (KABUK2).
Source: UniProtKB/Swiss-Prot O15550, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.
Written for the whole epigenetic regulation family, not for KDM6A specifically.
Mentioned in 1 corpus record
- Powers · Reddit commentCurated Powers pick
Re: Im going to be taking the week off next week to…
u/drwillpowers · r/DrWillPowers
Replying to a post-letrozole case with PFS-identical symptoms (a Klinefelter patient), Powers frames PFS and PSSD as the same mechanism in different flavors — inborn metabolic error plus drug, with recovery blocked by an epigenetic glitch — and notes…
ARID1AHDAC10KDM6APRH-15042026-04-19T00:13:31ZPFSPSSDPowers Reddit history
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