Pathway candidateNCBI-verifiedprotein-coding

MBD1

methyl-CpG binding domain protein 1

NCBI Gene: 4152 Ensembl GeneCards UniProt: Q9UIS9

Pathway candidate — not linked to PFS or PSSD by any record here

MBD1 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in MBD1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 18 (epigenetic regulation). The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Methyl-CpG-binding domain protein 1
Function: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Subcellular location: Nucleus; Nucleus matrix; Nucleus speckle; Chromosome.
Tissue specificity: Widely expressed.

Source: UniProtKB/Swiss-Prot Q9UIS9, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for MBD1 specifically.

Mentioned in 0 corpus records

No corpus record names MBD1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Methyl-CpG-binding domain protein 1
Function: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Subcellular location: Nucleus; Nucleus matrix; Nucleus speckle; Chromosome.
Tissue specificity: Widely expressed.