Pathway candidateNCBI-verifiedprotein-coding

MBD2

methyl-CpG binding domain protein 2

NCBI Gene: 8932 Ensembl GeneCards UniProt: Q9UBB5

Pathway candidate — not linked to PFS or PSSD by any record here

MBD2 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in MBD2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 18 (epigenetic regulation). DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Methyl-CpG-binding domain protein 2
Function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases to chromatin. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as a transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Subcellular location: Nucleus; Chromosome.
Tissue specificity: Highly expressed in brain, heart, kidney, stomach, testis and placenta.

Source: UniProtKB/Swiss-Prot Q9UBB5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for MBD2 specifically.

Mentioned in 0 corpus records

No corpus record names MBD2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Methyl-CpG-binding domain protein 2
Function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases to chromatin. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as a transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Subcellular location: Nucleus; Chromosome.
Tissue specificity: Highly expressed in brain, heart, kidney, stomach, testis and placenta.