MBD4
methyl-CpG binding domain 4, DNA glycosylase
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 3 (epigenetic regulation). The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Methyl-CpG-binding domain protein 4
- Function
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
- Subcellular location
Nucleus.
- Associated conditions
Tumor predisposition syndrome 2 (TPDS2); Melanoma, uveal, 1 (UVM1).
Source: UniProtKB/Swiss-Prot O95243, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.
Written for the whole epigenetic regulation family, not for MBD4 specifically.
Mentioned in 0 corpus records
No corpus record names MBD4 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).
Also in epigenetic regulation
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histone deacetylase 10
chr 22· Epigenetic regulation· 11 records - ARID1APowers
AT-rich interaction domain 1A
chr 1· Epigenetic regulation· 10 records - CHD8Powers
chromodomain helicase DNA binding protein 8
chr 14· Epigenetic regulation· 9 records - CHD4
chromodomain helicase DNA binding protein 4
chr 12· Epigenetic regulation· 1 record - CHD5
chromodomain helicase DNA binding protein 5
chr 1· Epigenetic regulation· 1 record - CHD6
chromodomain helicase DNA binding protein 6
chr 20· Epigenetic regulation· 1 record - CHD7
chromodomain helicase DNA binding protein 7
chr 8· Epigenetic regulation· 1 record - CHD9
chromodomain helicase DNA binding protein 9
chr 16· Epigenetic regulation· 1 record
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