Pathway candidateNCBI-verifiedprotein-coding

MECP2

methyl-CpG binding protein 2

NCBI Gene: 4204 Ensembl GeneCards UniProt: P51608

Pathway candidate — not linked to PFS or PSSD by any record here

MECP2 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in MECP2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (epigenetic regulation). DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Methyl-CpG-binding protein 2
Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).
Subcellular location: Nucleus.
Tissue specificity: Present in all adult somatic tissues tested.
Associated conditions: Angelman syndrome (AS); Intellectual developmental disorder, X-linked, syndromic 13 (MRXS13); Rett syndrome (RTT); Autism, X-linked 3 (AUTSX3); Encephalopathy, neonatal severe, due to MECP2 mutations (ENS-MECP2); Intellectual developmental disorder, X-linked, syndromic, Lubs type (MRXSL).

Source: UniProtKB/Swiss-Prot P51608, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for MECP2 specifically.

Mentioned in 0 corpus records

No corpus record names MECP2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Methyl-CpG-binding protein 2
Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).
Subcellular location: Nucleus.
Tissue specificity: Present in all adult somatic tissues tested.
Associated conditions: Angelman syndrome (AS); Intellectual developmental disorder, X-linked, syndromic 13 (MRXS13); Rett syndrome (RTT); Autism, X-linked 3 (AUTSX3); Encephalopathy, neonatal severe, due to MECP2 mutations (ENS-MECP2); Intellectual developmental disorder, X-linked, syndromic, Lubs type (MRXSL).