Pathway candidateNCBI-verifiedprotein-coding

PHF8

PHD finger protein 8

NCBI Gene: 23133 Ensembl GeneCards UniProt: Q9UPP1

Pathway candidate — not linked to PFS or PSSD by any record here

PHF8 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in PHF8 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (epigenetic regulation). The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone lysine demethylase PHF8
Function (excerpt): Histone lysine demethylase with selectivity for mono- and dimethylated residues. It plays an essential role in cell cycle progression and rDNA transcription. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2). May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes.
Subcellular location: Nucleus; Nucleus, nucleolus.
Associated conditions: Intellectual developmental disorder, X-linked, syndromic, Siderius type (MRXSSD).

Source: UniProtKB/Swiss-Prot Q9UPP1, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for PHF8 specifically.

Mentioned in 0 corpus records

No corpus record names PHF8 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone lysine demethylase PHF8
Function (excerpt): Histone lysine demethylase with selectivity for mono- and dimethylated residues. It plays an essential role in cell cycle progression and rDNA transcription. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2). May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes.
Subcellular location: Nucleus; Nucleus, nucleolus.
Associated conditions: Intellectual developmental disorder, X-linked, syndromic, Siderius type (MRXSSD).