Pathway candidateNCBI-verifiedprotein-coding

RDH16

retinol dehydrogenase 16

Chromosome 12Steroid synthesis retinoid signaling

NCBI Gene: 8608 Ensembl GeneCards UniProt: O75452

Pathway candidate — not linked to PFS or PSSD by any record here

RDH16 is in the library because it belongs to the steroid synthesis / retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in RDH16 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (steroid hormone synthesis). Enables all-trans-retinol dehydrogenase (NAD+) activity; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity; and androsterone dehydrogenase activity. Involved in steroid metabolic process.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinol dehydrogenase 16
Function: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Also oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.
Pathway: Cofactor metabolism; retinol metabolism.
Subcellular location: Microsome membrane; Endoplasmic reticulum membrane.
Tissue specificity: Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung.

Source: UniProtKB/Swiss-Prot O75452, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid-synthesis enzymes sit directly on the pathways perturbed by 5-alpha-reductase inhibitors and SSRIs; inherited variation here is a candidate susceptibility factor for persistent post-drug phenotypes.

Written for the whole steroid synthesis / retinoid signaling family, not for RDH16 specifically.

Mentioned in 0 corpus records

No corpus record names RDH16 directly yet. It is in the library because it sits in a pathway the corpus tracks (Steroid synthesis, retinoid signaling).

Also in steroid hormone synthesis

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Retinol dehydrogenase 16
Function: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Also oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction.
Pathway: Cofactor metabolism; retinol metabolism.
Subcellular location: Microsome membrane; Endoplasmic reticulum membrane.
Tissue specificity: Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung.

Why its pathway is in the library

Written for the whole steroid synthesis / retinoid signaling family, not for RDH16 specifically.