Pathway candidateNCBI-verifiedprotein-coding

SETD1B

SET domain containing 1B, histone lysine methyltransferase

NCBI Gene: 23067 Ensembl GeneCards UniProt: Q9UPS6

Pathway candidate — not linked to PFS or PSSD by any record here

SETD1B is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in SETD1B is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 12 (epigenetic regulation). SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 ).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Histone-lysine N-methyltransferase SETD1B
Function: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity).
Subcellular location: Nucleus; Nucleus speckle; Chromosome; Cytoplasm.
Associated conditions: Intellectual developmental disorder with seizures and language delay (IDDSELD).

Source: UniProtKB/Swiss-Prot Q9UPS6, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for SETD1B specifically.

Mentioned in 0 corpus records

No corpus record names SETD1B directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

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Protein reference (UniProt)

Protein: Histone-lysine N-methyltransferase SETD1B
Function: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity).
Subcellular location: Nucleus; Nucleus speckle; Chromosome; Cytoplasm.
Associated conditions: Intellectual developmental disorder with seizures and language delay (IDDSELD).