Pathway candidateNCBI-verifiedprotein-coding

SIRT1

sirtuin 1

NCBI Gene: 23411 Ensembl GeneCards UniProt: Q96EB6

Pathway candidate — not linked to PFS or PSSD by any record here

SIRT1 is in the library because it belongs to the epigenetic regulation family. No study, report or commentary in the corpus names it, so a variant in SIRT1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (epigenetic regulation). Encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: NAD-dependent protein deacetylase sirtuin-1
Function (excerpt): NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction.
Subcellular location: Nucleus, PML body; Cytoplasm; Nucleus; Nucleus, nucleoplasm; Mitochondrion.
Tissue specificity: Widely expressed.

Source: UniProtKB/Swiss-Prot Q96EB6, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.

Written for the whole epigenetic regulation family, not for SIRT1 specifically.

Mentioned in 0 corpus records

No corpus record names SIRT1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Epigenetic regulation).

Also in epigenetic regulation

All 130 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: NAD-dependent protein deacetylase sirtuin-1
Function (excerpt): NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction.
Subcellular location: Nucleus, PML body; Cytoplasm; Nucleus; Nucleus, nucleoplasm; Mitochondrion.
Tissue specificity: Widely expressed.