Pathway candidateNCBI-verifiedprotein-coding

SLC10A1

solute carrier family 10 member 1

NCBI Gene: 6554 Ensembl GeneCards UniProt: Q14973

Pathway candidate — not linked to PFS or PSSD by any record here

SLC10A1 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC10A1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 14 (drug and xenobiotic transporters). The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hepatic sodium/bile acid cotransporter
Function: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.
Subcellular location: Cell membrane.
Tissue specificity: Expressed in liver. Expressed in placental trophoblasts.
Associated conditions: Hypercholanemia, familial, 2 (FHCA2).

Source: UniProtKB/Swiss-Prot Q14973, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC10A1 specifically.

Mentioned in 0 corpus records

No corpus record names SLC10A1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hepatic sodium/bile acid cotransporter
Function: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.
Subcellular location: Cell membrane.
Tissue specificity: Expressed in liver. Expressed in placental trophoblasts.
Associated conditions: Hypercholanemia, familial, 2 (FHCA2).