Pathway candidateNCBI-verifiedprotein-coding

SLC10A2

solute carrier family 10 member 2

NCBI Gene: 6555 Ensembl GeneCards UniProt: Q12908

Pathway candidate — not linked to PFS or PSSD by any record here

SLC10A2 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC10A2 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 13 (drug and xenobiotic transporters). Encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Ileal sodium/bile acid cotransporter
Function: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.
Subcellular location: Membrane.
Tissue specificity: Mainly expressed in ileum and kidney, lower expression in cecum.
Associated conditions: Bile acid malabsorption, primary, 1 (PBAM1).

Source: UniProtKB/Swiss-Prot Q12908, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC10A2 specifically.

Mentioned in 0 corpus records

No corpus record names SLC10A2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Ileal sodium/bile acid cotransporter
Function: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.
Subcellular location: Membrane.
Tissue specificity: Mainly expressed in ileum and kidney, lower expression in cecum.
Associated conditions: Bile acid malabsorption, primary, 1 (PBAM1).