Pathway candidateNCBI-verifiedprotein-coding

SLC16A1

solute carrier family 16 member 1

NCBI Gene: 6566 Ensembl GeneCards UniProt: P53985

Pathway candidate — not linked to PFS or PSSD by any record here

SLC16A1 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC16A1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (drug and xenobiotic transporters). The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Monocarboxylate transporter 1
Function (excerpt): Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart.
Subcellular location: Cell membrane; Basolateral cell membrane; Apical cell membrane.
Tissue specificity: Widely expressed. Detected in heart and in blood lymphocytes and monocytes (at protein level).
Associated conditions: Symptomatic deficiency in lactate transport (SDLT); Hyperinsulinemic hypoglycemia, familial, 7 (HHF7); Monocarboxylate transporter 1 deficiency (MCT1D).

Source: UniProtKB/Swiss-Prot P53985, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC16A1 specifically.

Mentioned in 0 corpus records

No corpus record names SLC16A1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Monocarboxylate transporter 1
Function (excerpt): Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart.
Subcellular location: Cell membrane; Basolateral cell membrane; Apical cell membrane.
Tissue specificity: Widely expressed. Detected in heart and in blood lymphocytes and monocytes (at protein level).
Associated conditions: Symptomatic deficiency in lactate transport (SDLT); Hyperinsulinemic hypoglycemia, familial, 7 (HHF7); Monocarboxylate transporter 1 deficiency (MCT1D).