Pathway candidateNCBI-verifiedprotein-coding

SLC22A1

solute carrier family 22 member 1

NCBI Gene: 6580 Ensembl GeneCards UniProt: O15245

Pathway candidate — not linked to PFS or PSSD by any record here

SLC22A1 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC22A1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 6 (drug and xenobiotic transporters). Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 1
Function (excerpt): Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation.
Subcellular location: Basolateral cell membrane; Apical cell membrane; Lateral cell membrane; Basal cell membrane; Cell membrane.
Tissue specificity: Widely expressed with high level in liver. In liver, expressed around the central vein. Expressed in kidney. Expressed in small intestine enterocytes. Localized to peritubular myoid cells, Leydig cells and moderately to the basal membrane of Sertoli cells in testes. Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract. Also expressed in skeletal muscle, stomach, spleen, heart, placentacolon, brain, granulycytes and lymphocytes.

Source: UniProtKB/Swiss-Prot O15245, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A1 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 1
Function (excerpt): Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation.
Subcellular location: Basolateral cell membrane; Apical cell membrane; Lateral cell membrane; Basal cell membrane; Cell membrane.
Tissue specificity: Widely expressed with high level in liver. In liver, expressed around the central vein. Expressed in kidney. Expressed in small intestine enterocytes. Localized to peritubular myoid cells, Leydig cells and moderately to the basal membrane of Sertoli cells in testes. Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract. Also expressed in skeletal muscle, stomach, spleen, heart, placentacolon, brain, granulycytes and lymphocytes.