Pathway candidateNCBI-verifiedprotein-coding

SLC22A11

solute carrier family 22 member 11

NCBI Gene: 55867 Ensembl GeneCards UniProt: Q9NSA0

Pathway candidate — not linked to PFS or PSSD by any record here

SLC22A11 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC22A11 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (drug and xenobiotic transporters). The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 11
Function (excerpt): Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds. May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus. Maybe also be involved in placental urate homeostasis. Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates. Organic anion glutarate acts as conteranion for E1S renal uptake. Possible transport mode may also include DHEA-S/E1S exchange. Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-).
Subcellular location: Cell membrane; Apical cell membrane; Basal cell membrane.
Tissue specificity: Expressed in placental trophoblasts, syncytiotrophoblast and cytotrophoblast. Also located in the proximal tubules in kidneys.

Source: UniProtKB/Swiss-Prot Q9NSA0, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A11 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A11 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 11
Function (excerpt): Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds. May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus. Maybe also be involved in placental urate homeostasis. Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates. Organic anion glutarate acts as conteranion for E1S renal uptake. Possible transport mode may also include DHEA-S/E1S exchange. Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-).
Subcellular location: Cell membrane; Apical cell membrane; Basal cell membrane.
Tissue specificity: Expressed in placental trophoblasts, syncytiotrophoblast and cytotrophoblast. Also located in the proximal tubules in kidneys.