Pathway candidateNCBI-verifiedprotein-coding

SLC22A13

solute carrier family 22 member 13

NCBI Gene: 9390 Ensembl GeneCards UniProt: Q9Y226

Pathway candidate — not linked to PFS or PSSD by any record here

SLC22A13 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC22A13 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (drug and xenobiotic transporters). Encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 13
Function: Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions. Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption. Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate. Urate and orotate transports are Cl(-)-dependent. Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).
Subcellular location: Apical cell membrane.
Tissue specificity: Ubiquitous. Highly expressed in kidneys and to a weaker extent in brain, heart, and intestine. In kidneys, expressed in proximal convoluted tubule. In kidneys, also expressed in cortical collecting duct, whereas glomerulus and thick ascending limb exhibit no expression.

Source: UniProtKB/Swiss-Prot Q9Y226, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A13 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A13 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 13
Function: Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions. Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption. Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate. Urate and orotate transports are Cl(-)-dependent. Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).
Subcellular location: Apical cell membrane.
Tissue specificity: Ubiquitous. Highly expressed in kidneys and to a weaker extent in brain, heart, and intestine. In kidneys, expressed in proximal convoluted tubule. In kidneys, also expressed in cortical collecting duct, whereas glomerulus and thick ascending limb exhibit no expression.