Pathway candidateNCBI-verifiedprotein-coding

SLC22A14

solute carrier family 22 member 14

NCBI Gene: 9389 Ensembl GeneCards UniProt: Q9Y267

Pathway candidate — not linked to PFS or PSSD by any record here

SLC22A14 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC22A14 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (drug and xenobiotic transporters). Encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 14
Function: Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity). Required for sperm motility and normal sperm flagellar structure (By similarity).
Subcellular location: Mitochondrion inner membrane; Cell projection, cilium, flagellum membrane.
Tissue specificity: Ubiquitous.

Source: UniProtKB/Swiss-Prot Q9Y267, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A14 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A14 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Pathway candidateNCBI-verifiedprotein-coding

SLC22A14

solute carrier family 22 member 14

Chromosome 3Drug transporters

NCBI Gene: 9389 Ensembl GeneCards UniProt: Q9Y267

Pathway candidate — not linked to PFS or PSSD by any record here

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 14
Function: Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity). Required for sperm motility and normal sperm flagellar structure (By similarity).
Subcellular location: Mitochondrion inner membrane; Cell projection, cilium, flagellum membrane.
Tissue specificity: Ubiquitous.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A14 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A14 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.