Pathway candidateNCBI-verifiedprotein-coding

SLC22A24

solute carrier family 22 member 24

NCBI Gene: 283238 Ensembl GeneCards UniProt: Q8N4F4

Pathway candidate — not linked to PFS or PSSD by any record here

SLC22A24 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC22A24 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (drug and xenobiotic transporters). SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 ).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Steroid transmembrane transporter SLC22A24
Function: Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate.
Subcellular location: Cell membrane.
Tissue specificity: Isoform 1: Localized to the kidney. Highly specific expression pattern in the nephron, localized to segment 3 of the proximal tubule. Isoform 2: Localized to the kidney. Highly specific expression pattern in the nephron, localized to segment 3 of the proximal tubule.

Source: UniProtKB/Swiss-Prot Q8N4F4, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A24 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A24 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Steroid transmembrane transporter SLC22A24
Function: Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate.
Subcellular location: Cell membrane.
Tissue specificity: Isoform 1: Localized to the kidney. Highly specific expression pattern in the nephron, localized to segment 3 of the proximal tubule. Isoform 2: Localized to the kidney. Highly specific expression pattern in the nephron, localized to segment 3 of the proximal tubule.