Pathway candidateNCBI-verifiedprotein-coding

SLC22A5

solute carrier family 22 member 5

NCBI Gene: 6584 Ensembl GeneCards UniProt: O76082

Pathway candidate — not linked to PFS or PSSD by any record here

SLC22A5 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC22A5 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 5 (drug and xenobiotic transporters). Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Organic cation/carnitine transporter 2
Function: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3. In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from B.subtilis which induces cytoprotective heat shock proteins contributing to intestinal homeostasis. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable).
Subcellular location: Cell membrane; Apical cell membrane; Basal cell membrane; Endoplasmic reticulum.
Tissue specificity: Strongly expressed in kidney, skeletal muscle, heart and placenta. Primarily expressed by surface epithelial cells of the colon (at protein level). Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. In testis, localized to Sertoli cell basal membranes, peritubular myoid cells and Leydig cells.
Associated conditions: Systemic primary carnitine deficiency (CDSP).

Source: UniProtKB/Swiss-Prot O76082, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A5 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A5 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Organic cation/carnitine transporter 2
Function: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3. In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from B.subtilis which induces cytoprotective heat shock proteins contributing to intestinal homeostasis. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable).
Subcellular location: Cell membrane; Apical cell membrane; Basal cell membrane; Endoplasmic reticulum.
Tissue specificity: Strongly expressed in kidney, skeletal muscle, heart and placenta. Primarily expressed by surface epithelial cells of the colon (at protein level). Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. In testis, localized to Sertoli cell basal membranes, peritubular myoid cells and Leydig cells.
Associated conditions: Systemic primary carnitine deficiency (CDSP).