Pathway candidateNCBI-verifiedprotein-coding

SLC22A6

solute carrier family 22 member 6

NCBI Gene: 9356 Ensembl GeneCards UniProt: Q4U2R8

Pathway candidate — not linked to PFS or PSSD by any record here

SLC22A6 is in the library because it belongs to the drug transporters family. No study, report or commentary in the corpus names it, so a variant in SLC22A6 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (drug and xenobiotic transporters). The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The protein is an integral membrane protein and may be localized to the basolateral membrane.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 6
Function (excerpt): Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP.
Subcellular location: Basolateral cell membrane; Basal cell membrane.
Tissue specificity: Strongly expressed in kidney. Expressed at lower level in liver, skeletal muscle, brain and placenta. In kidney, found at the basolateral membrane of the proximal tubule. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and vascular endothelial cells.

Source: UniProtKB/Swiss-Prot Q4U2R8, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Transporters set systemic exposure to finasteride/SSRIs and clear conjugated steroid metabolites — directly relevant to both drug pharmacokinetics and Powers' clearance-centered PFS mechanism.

Written for the whole drug transporters family, not for SLC22A6 specifically.

Mentioned in 0 corpus records

No corpus record names SLC22A6 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug transporters).

Also in drug and xenobiotic transporters

All 62 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Solute carrier family 22 member 6
Function (excerpt): Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP.
Subcellular location: Basolateral cell membrane; Basal cell membrane.
Tissue specificity: Strongly expressed in kidney. Expressed at lower level in liver, skeletal muscle, brain and placenta. In kidney, found at the basolateral membrane of the proximal tubule. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and vascular endothelial cells.